2. Academic Validation
  3. Growth inhibition of pancreatic cancer by targeted delivery of gemcitabine via fucoidan-coated pH-sensitive liposomes

Growth inhibition of pancreatic cancer by targeted delivery of gemcitabine via fucoidan-coated pH-sensitive liposomes

  • Int J Biol Macromol. 2024 Aug 5;277(Pt 3):134517. doi: 10.1016/j.ijbiomac.2024.134517.
Zhenjiang Zheng 1,  Mengfei Li 2,  Jianchen Yang 3,  Xintao Zhou 2,  Yonghua Chen 1,  Epiphane K Silli 2,  Jiali Tang 2,  Songlin Gong 1,  Yuan Yuan 1,  Yihao Zong 4,  Jianping Kong 5,  Pu Chen 5,  Lingxi Yu 5,  Shujun Luo 5,  Ying Wang 6,  Chunlu Tan 7
Affiliations

Affiliations

  • 1 Division of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  • 2 School of Life Sciences and Technology, China Pharmaceutical University, Nanjing, Jiangsu 211198, China.
  • 3 Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA.
  • 4 School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, China.
  • 5 School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, China.
  • 6 School of Life Sciences and Technology, China Pharmaceutical University, Nanjing, Jiangsu 211198, China. Electronic address: ywang@cpu.edu.cn.
  • 7 Division of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address: chunlutan@163.com.
PMID: 39111497 DOI: 10.1016/j.ijbiomac.2024.134517
Abstract

Fucoidan-coated pH sensitive liposomes were designed for targeted delivery of gemcitabine (FU-GEM PSL) to treat pancreatic Cancer (PC). FU-GEM PSL had a particle size of 175.3 ± 4.9 nm, zeta potential of -19.0 ± 3.7 mV, encapsulation efficiency (EE) of 74.05 ± 0.17 %, and drug loading (DL) of 21.27 ± 0.05 %. Cell experiments in vitro showed that FU-GEM PSL could increase the release of GEM and drug concentration, and could inhibit tumor cell proliferation by affecting the cell cycle. FU-GEM PSL entered cells through macropinocytosis and caveolin-mediated endocytosis to exert effects. Meanwhile, the expression of P-selectin was detected in human tissues, demonstrating the feasibility of targeting FU. Moreover, combined with animal experiments in vivo, FU-GEM PSL could inhibit the development of PC. Furthermore, anti-tumor experiments in vivo carried on BALB/c mice indicated that FU-GEM PSL had tumor suppression abilities and safety. Therefore, FU-GEM PSL is a promising formulation for PC therapy.

Keywords

Fucoidan; PH-sensitive liposomes; Pancreatic cancer; Targeting drug delivery.

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