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  3. Wogonin Inhibits Apoptosis and Necroptosis Induced by Nephropathogenic Infectious Bronchitis Virus in Chicken Renal Tubular Epithelial Cells

Wogonin Inhibits Apoptosis and Necroptosis Induced by Nephropathogenic Infectious Bronchitis Virus in Chicken Renal Tubular Epithelial Cells

  • Int J Mol Sci. 2024 Jul 27;25(15):8194. doi: 10.3390/ijms25158194.
Qiurong Qi 1,  Ying Li 1,  Mengbing Ding 1,  Cheng Huang 1,  Salma Mbarouk Omar 1,  Yan Shi 2,  Ping Liu 1,  Gaofeng Cai 1,  Zhanhong Zheng 1,  Xiaoquan Guo 1,  Xiaona Gao 1
Affiliations

Affiliations

  • 1 Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.
  • 2 School of Computer and Information Engineering, Jiangxi Agricultural University, Nanchang 330045, China.
PMID: 39125764 DOI: 10.3390/ijms25158194
Abstract

NIBV is an acute and highly contagious virus that has a major impact on the poultry industry. Wogonin, as a flavonoid drug, has Antiviral effects, but there have been no reports indicating its role in renal injury caused by NIBV Infection. The aim of this study is to investigate the Antiviral effect of wogonin against NIBV. Renal tubular epithelial cells were isolated and cultured, and divided into four groups: Con, Con+Wog, NIBV and NIBV+Wog. We found that wogonin significantly inhibited the copy number of NIBV and significantly alleviated NIBV-induced Cell Apoptosis and Necrosis. Moreover, wogonin inhibited the reduction in mitochondrial membrane potential and the aberrant opening of mPTP caused by NIBV. In conclusion, wogonin can protect renal tubular epithelial cells from damage by inhibiting the replication of NIBV and preventing mitochondrial Apoptosis and Necroptosis induced by NIBV.

Keywords

apoptosis; necroptosis; nephropathogenic infectious bronchitis virus; renal tubular epithelial cells; wogonin.

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