2. Academic Validation
  3. Elevated concentrations of amyloid-β oligomers and their proapoptotic effects on age-related cataract

Elevated concentrations of amyloid-β oligomers and their proapoptotic effects on age-related cataract

  • FASEB J. 2024 Sep;38(17):e23861. doi: 10.1096/fj.202301281RR.
Peimin Lin 1 2 3 4,  Jie Xu 1 2 3 4,  Fan Yang 1 2 3 4,  Dan Li 1 2 3 4,  Rong Zhang 1 2 3 4,  Yongxiang Jiang 1 2 3 4,  Tianyu Zheng 1 2 3 4
Affiliations

Affiliations

  • 1 Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
  • 2 Eye Institute, Eye & ENT Hospital, Fudan University, Shanghai, China.
  • 3 NHC Key laboratory of Myopia and Related Eye Diseases, Shanghai, China.
  • 4 Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China.
PMID: 39247969 DOI: 10.1096/fj.202301281RR
Abstract

Recently, Amyloid-β oligomers (AβOs) have been studied as the primary pathogenic substances in Alzheimer's disease (AD). Our previous study revealed that the Aβ expression level is closely related to ARC progression. Here, we demonstrated that the accumulation of AβOs in the lens epithelium of age-related cataract (ARC) patients increased during ARC progression and that this alteration was consistent with the changes in mitochondrial function, oxidative stress, and cellular Apoptosis. In vitro, human lens epithelial cells (HLECs) treated with AβOs exhibited CA2+ dyshomeostasis, impaired mitochondrial function, elevated oxidative stress levels, and increased Apoptosis. Moreover, the proapoptotic effect of AβOs was alleviated after the uptake of mitochondrial CA2+ was inhibited. These results establish that AβOs may promote HLEC Apoptosis by inducing mitochondrial CA2+ overload, thus preliminarily revealing the possible association between the accumulation of AβOs and Other pathological processes in ARC.

Keywords

ARC; AβO; age‐related cataract; amyloid‐β oligomer; calcium homeostasis.

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