2. Academic Validation
  3. Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis

Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis

  • Cell Metab. 2024 Nov 5;36(11):2367-2382.e5. doi: 10.1016/j.cmet.2024.08.007.
Fopei Ma 1,  Zhuang Li 2,  Haihua Liu 3,  Shixian Chen 4,  Songyuan Zheng 4,  Junqing Zhu 4,  Hao Shi 5,  Haixin Ye 5,  Zhantu Qiu 5,  Lei Gao 5,  Bingqi Han 5,  Qian Yang 4,  Xing Wang 4,  Yang Zhang 6,  Lifang Cheng 4,  Huijie Fan 7,  Shuaijun Lv 8,  Xiaoshan Zhao 8,  Hongwei Zhou 9,  Juan Li 10,  Mukeng Hong 11
Affiliations

Affiliations

  • 1 Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou 510000, China; Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510000, China.
  • 2 Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510000, China. Electronic address: jiandandjx@smu.edu.cn.
  • 3 Department of Obstetrics & Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510000, China.
  • 4 Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou 510000, China.
  • 5 Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510000, China.
  • 6 Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou 510000, China.
  • 7 Department of Traditional Chinese Medicine, People's Hospital of Yangjiang, Yangjiang 529500, China.
  • 8 School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
  • 9 Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510000, China. Electronic address: biodegradation@gmail.com.
  • 10 Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou 510000, China; Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510000, China. Electronic address: lijuan@smu.edu.cn.
  • 11 Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou 510000, China. Electronic address: hmksmu@163.com.
PMID: 39260371 DOI: 10.1016/j.cmet.2024.08.007
Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune condition characterized by inflammatory activity with distinct rhythmic fluctuations. However, the precise mechanisms governing these inflammatory rhythms remain elusive. Here, we explore the interaction between dietary patterns, gut microbiota diurnal oscillations, and the rhythmicity of RA in both collagen-induced arthritis (CIA) mice and patients with RA and highlight the significance of dietary timing in modulating RA inflammatory rhythms linked to gut microbiota. Specifically, we discovered that Parabacteroides distasonis (P. distasonis) uses β-glucosidase (β-GC) to release glycitein (GLY) from the diet in response to daily nutritional cues, influencing RA inflammatory rhythms dependent on the Sirtuin 5-nuclear factor-κB (SIRT5-NF-κB) axis. Notably, we validated the daily fluctuations of P. distasonis-β-GC-GLY in patients with RA through continuous sampling across day-night cycles. These findings underscore the crucial role of dietary timing in RA rhythmicity and propose potential clinical implications for novel therapeutic strategies to alleviate arthritis.

Keywords

biological rhythm; feeding rhythm; gut microbiota; rheumatoid arthritis.

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