2. Academic Validation
  3. Melatonin Ameliorates Abnormal Sleep-Wake Behavior via Facilitating Lipid Metabolism in a Zebrafish Model of Parkinson's Disease

Melatonin Ameliorates Abnormal Sleep-Wake Behavior via Facilitating Lipid Metabolism in a Zebrafish Model of Parkinson's Disease

  • Neurosci Bull. 2024 Sep 16. doi: 10.1007/s12264-024-01299-8.
Meng-Zhu Pang # 1 2,  Han-Xing Li # 1,  Xue-Qin Dai 2,  Xiao-Bo Wang 2,  Jun-Yi Liu 3,  Yun Shen 1,  Xing Xu 1,  Zhao-Min Zhong 4 5,  Han Wang 4 5,  Chun-Feng Liu 6 7 8,  Fen Wang 9 10
Affiliations

Affiliations

  • 1 Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
  • 2 Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institutes of Neuroscience, Soochow University, Suzhou, 215123, China.
  • 3 Department of Neurology, The Fourth Affiliated Hospital of Soochow University, Suzhou, 215000, China.
  • 4 Center for Circadian Clocks, Soochow University, Suzhou, 215123, China.
  • 5 School of Biology & Basic Medical Sciences, Medical College, Soochow University, Suzhou, 215123, China.
  • 6 Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. liuchunfeng@suda.edu.cn.
  • 7 Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institutes of Neuroscience, Soochow University, Suzhou, 215123, China. liuchunfeng@suda.edu.cn.
  • 8 Department of Neurology, Xiongan Xuanwu Hospital, Xiongan, 071700, China. liuchunfeng@suda.edu.cn.
  • 9 Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. wangfen_1982@126.com.
  • 10 Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institutes of Neuroscience, Soochow University, Suzhou, 215123, China. wangfen_1982@126.com.
  • # Contributed equally.
PMID: 39283564 DOI: 10.1007/s12264-024-01299-8
Abstract

Sleep-wake disorder is one of the most common nonmotor symptoms of Parkinson's disease (PD). Melatonin has the potential to improve sleep-wake disorder, but its mechanism of action is still unclear. Our data showed that melatonin only improved the motor and sleep-wake behavior of a zebrafish PD model when Melatonin Receptor 1 was present. Thus, we explored the underlying mechanisms by applying a rotenone model. After the PD zebrafish model was induced by 10 nmol/L rotenone, the motor and sleep-wake behavior were assessed. In situ hybridization and real-time quantitative PCR were used to detect the expression of melatonin receptors and lipid-metabolism-related genes. In the PD model, we found abnormal lipid metabolism, which was reversed by melatonin. This may be one of the main pathways for improving PD sleep-wake disorder.

Keywords

Lipid metabolism; Melatonin; Melatonin receptor 1; Parkinson’s disease; Sleep-wake disorder; Zebrafish.

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