2. Academic Validation
  3. Therapeutic potential of plasma-treated solutions in atopic dermatitis

Therapeutic potential of plasma-treated solutions in atopic dermatitis

  • Free Radic Biol Med. 2024 Oct 18:225:482-493. doi: 10.1016/j.freeradbiomed.2024.10.290.
Tingyi Yin 1,  Shuo Feng 1,  He Zhu 2,  Ruimin Bai 1,  Xinyi Gan 1,  Ke He 1,  Wenqian Du 1,  Baochen Cheng 1,  Xinyi Liu 1,  Zifeng Wang 2,  Hao Zhang 3,  Yan Zheng 4,  Dingxin Liu 5
Affiliations

Affiliations

  • 1 Department of Dermatology, The First Affiliated Hospital, Xi'an Jiaotong University Xi'an, Shaanxi, 710061, China.
  • 2 State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, China.
  • 3 State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, China. Electronic address: zhang216@mail.xjtu.edu.cn.
  • 4 Department of Dermatology, The First Affiliated Hospital, Xi'an Jiaotong University Xi'an, Shaanxi, 710061, China. Electronic address: zenyan66@126.com.
  • 5 State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, China. Electronic address: liudingxin@mail.xjtu.edu.cn.
PMID: 39426754 DOI: 10.1016/j.freeradbiomed.2024.10.290
Abstract

Atopic Dermatitis (AD) is a prevalent inflammatory skin disease that is currently incurable. Plasma-treated solutions (PTS) (e.g., culture media, water, or normal saline, previously exposed to plasma) are being studied as novel therapy. Recently, PTS is gaining attention due to its advantages over non-thermal plasma (also known as cold atmospheric plasma). Thus, we explore the application of PTS in treating AD. In vivo experiments demonstrated that PTS significantly alleviated AD-like symptoms. It reduced mast cell and macrophage infiltration, decreased scratching times and serum IgE levels. These therapeutic effects of PTS on AD mice were associated with the activation of the antioxidant molecule Nrf2. In vitro experiments revealed that PTS could decrease ROS level and regulate cytokine expression (such as IL-6, IL-10, IL-13 and CCL17) in TNF-α/IFN-γ-stimulated keratinocytes and LPS-stimulated M1 macrophages. Additionally, PTS could upregulate the expression of antioxidant stress molecules such as Nrf2, HO-1, NQO1 and PPAR-γ in both cell types. Overall, PTS demonstrated potent therapeutic potential for AD without notable side effects. Our research provided a promising approach to AD treatment and may serve as a potential therapeutic strategy in Other inflammatory skin diseases.

Keywords

Atopic dermatitis; Inflammation; Non-thermal plasma; Nrf2; Plasma-treated solutions.

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