2. Academic Validation
  3. Unleashing the Power of Cold Atmospheric Plasma: Inducing Mitochondria Damage-Mediated Mitotic Catastrophe

Unleashing the Power of Cold Atmospheric Plasma: Inducing Mitochondria Damage-Mediated Mitotic Catastrophe

  • Adv Sci (Weinh). 2024 Dec;11(46):e2401842. doi: 10.1002/advs.202401842.
Shengjie Peng 1 2,  Yue Feng 1 3,  K N Yu 4 5,  Lijun Wu 6,  Guodong Chen 1 7,  Miaomiao Yang 1 2,  Lele Zhao 1 3,  Wei Cao 1,  Qianwen Cui 1 2,  Lianjun Chen 8,  Quan Li 9,  Yifan Huang 2,  Cheng Cheng 10,  Fengqin Zhu 7,  Wei Han 1 4 7 11
Affiliations

Affiliations

  • 1 Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, P. R. China.
  • 2 University of Science and Technology of China, Hefei, 230026, P. R. China.
  • 3 Teaching and Research Section of Nuclear Medicine, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, P. R. China.
  • 4 Department of Physics, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong, P. R. China.
  • 5 State Key Laboratory in Marine Pollution, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong, P. R. China.
  • 6 Institute of Physical Science and Information Technology, Anhui University, Hefei, 230031, P. R. China.
  • 7 Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, 230031, P. R. China.
  • 8 School of Biology, Food and Environment, Hefei University, Hefei, 230601, P. R. China.
  • 9 Department of Radiation Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou, 325035, P. R. China.
  • 10 Institute of Plasma Physics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, P. R. China.
  • 11 Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions and School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou, 215006, P. R. China.
PMID: 39440523 DOI: 10.1002/advs.202401842
Abstract

Despite the promise of cold atmospheric plasma (CAP) for Cancer treatment, the challenges associated with the treatment of solid tumors and penetration depth limitations remain, restricting its clinical application. Here, biological evidence is provided that the killing effect of CAP treatment is confined to less than 500 µm subcutaneously and the actual biological dose decreased gradually with depth for the first time, indicating that the limited penetration depth has become an urgent problem that demands immediate solutions. Significantly, it is showed that different from high-dose treatments, CAP decreased the doses to the low-dose range but still exhibited anti-tumor effects via mitotic catastrophe. Unlike radiotherapy or chemotherapy, low-dose CAP treatment induces mitochondrial structural damage and dysfunction, disrupts energy metabolism and redox balance, and results in mitotic catastrophe. Collectively, these findings suggest that better understanding and taking full advantage of the dose-response gradient effect of CAP is a potential strategy to prompt its clinical application beyond improving CAP penetration.

Keywords

anti‐tumor effect; cold atmospheric plasma; mitochondria damage; mitotic catastrophe.

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