2. Academic Validation
  3. Mucus-Penetrable Biomimetic Nanoantibiotics for Pathogen-Induced Pneumonia Treatment

Mucus-Penetrable Biomimetic Nanoantibiotics for Pathogen-Induced Pneumonia Treatment

  • ACS Nano. 2024 Nov 12;18(45):31349-31359. doi: 10.1021/acsnano.4c10837.
Yue Wang 1 2,  Qihang Ding 3,  Gongcheng Ma 2,  Zhiwei Zhang 2,  Jiaqi Wang 1,  Chang Lu 1,  Chunbai Xiang 2,  Kun Qian 4,  Jun Zheng 1,  Yaming Shan 5,  Pengfei Zhang 2 6,  Zhen Cheng 4 7,  Ping Gong 2 6,  Qi Zhao 1
Affiliations

Affiliations

  • 1 Cancer Center, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, China.
  • 2 Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen 518055, China.
  • 3 Department of Chemistry, Korea University, Seoul 02841, Korea.
  • 4 State Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • 5 National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin 130012, China.
  • 6 Sino-Euro Center of Biomedicine and Health, Luohu, Shenzhen 518024, China.
  • 7 Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, China.
PMID: 39485232 DOI: 10.1021/acsnano.4c10837
Abstract

Bacterial pneumonia has garnered significant attention in the realm of infectious diseases owing to a surge in the incidence of severe infections coupled with the growing scarcity of efficacious therapeutic modalities. Antibiotic treatment is still an irreplaceable method for Bacterial pneumonia because of its strong bactericidal activity and good clinical efficacy. However, the mucus layer forming after a Bacterial infection in the lungs has been considered as the "Achilles' heels" facing the clinical application of such treatment. Herein, traceable biomimetic nanoantibiotics (BioNanoCFPs) were developed by loading indacenodithieno[3,2-b]thiophene (ITIC) and cefoperazone (CFP) in nanoplatforms coated with natural killer (NK) cell membranes. The BioNanoCFP exhibited excellent demonstrated mucus-penetrating abilities, facilitating their arrival at the Infection site. The presence of Toll-like receptors in the NK cell membrane rendered the BioNanoCFP with the capability to recognize pathogen-associated molecular patterns within bacteria, allowing precise targeting of Bacterial colonization sites and achieving substantial therapeutic efficacy. Overall, our findings demonstrate the viability and desirability of using NK cell membrane-mediated drug delivery as a promising strategy for precision treatment.

Keywords

antibacterial treatments; bacterial pneumonia; biomimetic; mucus layer; natural killer cells.

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