2. Academic Validation
  3. Three-Dimensional Semiconductor Network as Regulators of Energy Metabolism Drives Angiogenesis in Bone Regeneration

Three-Dimensional Semiconductor Network as Regulators of Energy Metabolism Drives Angiogenesis in Bone Regeneration

  • ACS Nano. 2024 Nov 26;18(47):32602-32616. doi: 10.1021/acsnano.4c09971.
Youzhun Fan 1,  Jiwei Sun 2 3,  Wenjie Fan 2 3,  Xianwei Zhong 4,  Zhaoyi Yin 5,  Bin Su 6,  Jing Yao 2 3,  Xinyu Hong 2 3,  Jinxia Zhai 1,  Zhengao Wang 1,  Haoyan Chen 1,  Fengyuan Guo 2 3,  Xiufang Wen 4,  Chengyun Ning 1,  Lili Chen 2 3,  Peng Yu 1
Affiliations

Affiliations

  • 1 School of Materials Science and Engineering, Guangdong Engineering Technology Research Center of Metallic Materials Surface Functionalization, National Engineering Research Center for Tissue Restoration and Reconstruction, Medical Devices Research and Testing Center, South China University of Technology, Guangzhou 510641, China.
  • 2 Department of Stomatology, School of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • 3 Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430022, China.
  • 4 School of Chemistry and Chemical Engineering, Guangdong Provincial Key Lab of Green Chemical Product Technology, South China University of Technology, Guangzhou 510641, China.
  • 5 Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China.
  • 6 State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430030, China.
PMID: 39530623 DOI: 10.1021/acsnano.4c09971
Abstract

Insufficient vascularization is a primary cause of bone implantation failure. The management of energy metabolism is crucial for the achievement of vascularized osseointegration. In light of the bone semiconductor property and the electric property of semiconductor heterojunctions, a three-dimensional semiconductor heterojunction network (3D-NTBH) implant has been devised with the objective of regulating cellular energy metabolism, thereby driving angiogenesis for bone regeneration. The three-dimensional heterojunction interfaces facilitate electron transfer and establish internal electric fields at the nanoscale interfaces. The 3D-NTBH was found to noticeably accelerate glycolysis in endothelial cells, thereby rapidly providing energy to support cellular metabolic activities and ultimately driving angiogenesis within the bone tissue. Molecular dynamic simulations have demonstrated that the 3D-NTBH facilitates the exposure of fibronectin's Arg-Gly-Asp peptide binding site, thereby regulating the glycolysis of endothelial cells. Further evidence suggests that 3D-NTBH promotes early vascular network reconstruction and bone regeneration in vivo. The findings of this research offer a promising research perspective for the design of vascularizing implants.

Keywords

angiogenesis; energy metabolism; heterojunction; semiconductor implant; tissue regeneration.

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