2. Academic Validation
  3. SN promote retinal pathological neovascularization through activation of EGFR, IR and IGF-1R

SN promote retinal pathological neovascularization through activation of EGFR, IR and IGF-1R

  • Exp Eye Res. 2025 Jan:250:110158. doi: 10.1016/j.exer.2024.110158.
Wen Deng 1,  Kongqian Huang 1,  Ling Cui 1,  Zhijie Niu 2,  Diyang Ke 3,  Li Jiang 1,  Ningning Tang 1,  Haibin Zhong 1,  Qianqian Lan 1,  Fan Xu 4,  Fen Tang 5
Affiliations

Affiliations

  • 1 Department of Ophthalmology, The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Key Laboratory of Eye Health & Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology &Institute of Ophthalmic Diseases, Guangxi Academy of Medical Sciences, Nanning, 530021, China.
  • 2 Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
  • 3 Department of Ophthalmology, The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Key Laboratory of Eye Health & Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology &Institute of Ophthalmic Diseases, Guangxi Academy of Medical Sciences, Nanning, 530021, China; Guilin Medical University, Guilin, 541001, China.
  • 4 Department of Ophthalmology, The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Key Laboratory of Eye Health & Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology &Institute of Ophthalmic Diseases, Guangxi Academy of Medical Sciences, Nanning, 530021, China. Electronic address: oph_fan@163.com.
  • 5 Department of Ophthalmology, The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Key Laboratory of Eye Health & Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology &Institute of Ophthalmic Diseases, Guangxi Academy of Medical Sciences, Nanning, 530021, China. Electronic address: tangf7@mail2.sysu.edu.cn.
PMID: 39549871 DOI: 10.1016/j.exer.2024.110158
Abstract

Secretoneurin (SN) is a neuropeptide derived from secretogranin II (SgII), mainly are involved in neuroendocrine system. The present study is aimed to investigate the role of SN in retinal pathological neovascularization and physiological vasculature. In the study, we found the overexpression of SgII in retina of Oxygen-Induced Retinopathy (OIR) mouse model, and SgII knockdown could alleviate pathological retinal neovascularization in OIR. Conversely, SgII knockdown have no detectable effect in embryonic physiological vasculature. Experiments in vitro and in vivo further verified SN's angiogenic effect on the eye. In further, we identified that SN promoted angiogenesis via activation of Epidermal Growth Factor Receptor (EGFR), Insulin Receptor (IR), and Insulin-like Growth Factor 1 Receptor (IGF-1R), and followed by the phosphorylation of PI3K-AKT-mTOR signaling. In summarize, our study suggests that SN might be a postnatal angiogenic factor, which was critically involved in retinal pathological neovascularization, but not in embryonic retinal physiological vasculature. Moreover, we identified the receptors and the downstream signaling involved in SN induced retinal angiogenesis.

Keywords

Angiogenesis; Embryonic vasculature; Granin family; Retinal pathological neovascularization; Secretogranin II; Secretoneurin.

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