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  3. Curcumin alleviated dextran sulfate sodium-induced ulcerative colitis via inhibition of the Wnt/β-catenin signaling pathway and regulation of the differentiation of intestinal stem cells

Curcumin alleviated dextran sulfate sodium-induced ulcerative colitis via inhibition of the Wnt/β-catenin signaling pathway and regulation of the differentiation of intestinal stem cells

  • Toxicol Appl Pharmacol. 2025 Jan:494:117175. doi: 10.1016/j.taap.2024.117175.
Shaojie Liang 1,  Kun Wang 2,  Dabin Mao 2,  Qianqian Ouyang 3,  Xiaoping Lv 4,  Liwei Xie 5,  Dajian Zhu 6
Affiliations

Affiliations

  • 1 Maternal and Children's Health Research Institute, Shunde Maternal and Children's Hospital, Guangdong Medical University, Foshan 528300, China; The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang 524023, China.
  • 2 Maternal and Children's Health Research Institute, Shunde Maternal and Children's Hospital, Guangdong Medical University, Foshan 528300, China.
  • 3 The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang 524023, China; The Marine Biomedical Research Institute of Guangdong Zhanjiang, Guangdong Medical University, Zhanjiang 524023, China.
  • 4 Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
  • 5 State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510075, China. Electronic address: xielw@gdim.cn.
  • 6 Maternal and Children's Health Research Institute, Shunde Maternal and Children's Hospital, Guangdong Medical University, Foshan 528300, China. Electronic address: zdj123zhudajian123@126.com.
PMID: 39608729 DOI: 10.1016/j.taap.2024.117175
Abstract

In this study, we investigated the regulatory role of curcumin in the differentiation of intestinal stem cells (ISCs) in dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) model mice and explored whether this effect was mediated by the Wnt/β-catenin signaling pathway. We conducted experiments in DSS-induced UC model mice to observe changes in intestinal morphology through HE staining and detect the expression of key proteins in the Wnt/β-catenin signaling pathway. According to these findings, curcumin was found to have a significant impact on the differentiation of ISCs. These results indicated that curcumin inhibited the Wnt/β-catenin signaling pathway and restored ISC differentiation. The effects of curcumin on the Wnt/β-catenin signaling pathway were further confirmed using Wnt/β-catenin agonists. These findings provide a new perspective for understanding the behavior of ISCs in the context of inflammation and offer new insights into the development of novel therapeutic strategies and drugs for UC.

Keywords

Curcumin; Intestinal stem cell; SOX9; Ulcerative colitis; Wnt/β-catenin.

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