2. Academic Validation
  3. Self-Assembled Nanoparticles with Well-Defined Oligosaccharide Promote Osteogenesis by Regulating Golgi Stress Response

Self-Assembled Nanoparticles with Well-Defined Oligosaccharide Promote Osteogenesis by Regulating Golgi Stress Response

  • Adv Healthc Mater. 2025 Jan;14(3):e2402976. doi: 10.1002/adhm.202402976.
Pingping Niu 1,  Liman Zhao 2 3,  Jing Yang 2,  Yanan Ding 1,  Xiaoqiao Xu 1,  Sijin Li 1,  Lige Song 4,  Guosong Chen 2 5,  Yao Sun 1
Affiliations

Affiliations

  • 1 Shanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Oral Implantology, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai, 200072, China.
  • 2 The State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai, 200433, China.
  • 3 Shanghai Key Lab of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai, 200092, China.
  • 4 Department of Endocrinology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
  • 5 Greater Bay Area Institute of Precision Medicine (Guangzhou), Fudan University, Guangzhou, 511462, China.
PMID: 39618007 DOI: 10.1002/adhm.202402976
Abstract

Osteoporosis, a prevalent disease characterized by low bone density and increased fracture risk, poses significant health challenges for the elderly. Current treatments offer short-term benefits but are limited by long-term efficacy and adverse effects, highlighting the need for new strategies. Chondroitin sulfate Polysaccharides (CS), a major component of the bone matrix, are crucial for bone and cartilage health. However, their role in osteoporosis is understudied due to the heterogeneity of natural CS. we found reduced CS levels in osteoporosis patients and developed CS4-NP, a self-assembled tetrasaccharide nanoparticle that mimics CS's structure. CS4-NP, which efficiently delivers the active CS4, significantly improves bone mass in ovariectomized osteoporosis models. It activates the Activating Transcription Factor 4-Cystathionine gamma-Lyase signaling axis in pre-osteoblasts, enhancing osteogenesis. our findings suggest that CS4-NP, an oligosaccharide-based nanomaterial, could address the limitations of current treatments and provide a viable strategy for osteoporosis.

Keywords

chondroitin sulfate; glyco‐materials; nanoparticles; osteoporosis; self‐assembly.

Figures
Products