2. Academic Validation
  3. Hyperoside ameliorates neuropathic pain by modulating the astroglial reactivity in the vlPAG

Hyperoside ameliorates neuropathic pain by modulating the astroglial reactivity in the vlPAG

  • Neuropharmacology. 2025 Mar 15:266:110276. doi: 10.1016/j.neuropharm.2024.110276.
Tianchi Gao 1,  Chenghao Wang 2,  Xiaotong Yang 1,  Zhiwei He 1,  Yanqing Wang 1,  Wenli Mi 3
Affiliations

Affiliations

  • 1 Department of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
  • 2 Department of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai, 200032, China; College of Sports Medicine and Rehabilitation, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, 271016, China.
  • 3 Department of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai, 200032, China. Electronic address: wenlimi@fudan.edu.cn.
PMID: 39716641 DOI: 10.1016/j.neuropharm.2024.110276
Abstract

Hyperoside, a natural flavonoid, exhibits a wide range of biological activities, including analgesic effects on acute and chronic inflammatory pain. This study illustrates that repeated intraperitoneal administration or microinjection of hyperoside into the ventrolateral periaqueductal grey (vlPAG) alleviated mechanical allodynia, cold allodynia, and abnormal gait induced by spared nerve injury (SNI) in male mice. Furthermore, repeated hyperoside administration suppressed SNI-induced astrocyte reactivity in the vlPAG. Moreover, hyperoside alleviated the pain behaviors resulting from the pharmacogenetic activation of vlPAG astrocytes. These results suggest that hyperoside may effectively mitigate neuropathic pain and inhibit astroglial reactivity in the vlPAG, highlighting its potential as a viable therapeutic intervention for chronic neuropathic pain.

Keywords

Astrocyte; Hyperoside; Neuropathic pain; PAG.

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