2. Academic Validation
  3. Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis

Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis

  • Adv Mater. 2024 Dec 26:e2415543. doi: 10.1002/adma.202415543.
Penghao Ji 1,  Shuwen Qiu 1,  Junchao Huang 1,  Liping Wang 2,  Yuemei Wang 1,  Peng Wu 1,  Minfeng Huo 1,  Jianlin Shi 1 2
Affiliations

Affiliations

  • 1 Department of Orthopedics, Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science School of Medicine, School of Medicine, Tongji University, Shanghai, 200072, P. R. China.
  • 2 State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences, Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Chinese Academy of Medical Sciences (2021RU012), Shanghai, 200050, P. R. China.
PMID: 39726077 DOI: 10.1002/adma.202415543
Abstract

Rheumatoid arthritis (RA) is a kind of inflammation homeostasis disorder that dysfunctions the joints. Clinically, medications against RA focus simply on mitigating the focal inflammation, without considering pro-osteogenesis re-modeling of the bone microenvironment. In the present work, 2D layered calcium disilicide nanoparticles (CSNs) are fabricated by facile aqueous exfoliation. The hydrolysis of CSNs produces anti-oxidative H2, alkaline CA(OH)2, and silica. These moieties play significant roles in anti-oxidation, anti-inflammation, and pro-osteogenesis resulting in considerably better RA therapeutic consequences than anti-inflammation alone. Hydrogen gas is validated to eliminate excessive hydroxyl radicals and regulate macrophage re-polarization; the generated CA(OH)2 can neutralize the acidic microenvironment and inhibit the osteoclast activity; and, the dissolved CA2+ can effectively complex with phosphates to mineralize CA3(PO4)2, promoting the osteogenesis of the focal joint. The multifunctional performances of CSNs are further confirmed in arthritic mouse and rabbit models, providing an advanced and robust therapeutic strategy against RA with high biocompatibility and clinical transformable promises.

Keywords

2D nanomaterials; anti‐inflammation; hydrogen therapy; osteogenesis; rheumatoid arthritis.

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