2. Academic Validation
  3. Regulation of Bone Remodeling by Metal-Phenolic Networks for the Treatment of Systemic Osteoporosis

Regulation of Bone Remodeling by Metal-Phenolic Networks for the Treatment of Systemic Osteoporosis

  • ACS Appl Mater Interfaces. 2025 Jan 29;17(4):5995-6008. doi: 10.1021/acsami.4c18829.
Xi Chen 1,  Weihui Wu 1,  Wei Zhu 2,  Jiajing Zhou 3,  Jingqu Chen 4,  Zhixing Lin 4,  Sixian Zhang 1,  Frank Caruso 4,  Changsheng Liu 1
Affiliations

Affiliations

  • 1 Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center of Biomedical Materials Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
  • 2 MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.
  • 3 College of Biomass Science and Engineering, Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu 610065, China.
  • 4 Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.
PMID: 39818714 DOI: 10.1021/acsami.4c18829
Abstract

Osteoporosis is a systemic Metabolic Disease that impairs bone remodeling by favoring osteoclastic resorption over osteoblastic formation. Nanotechnology-based therapeutic strategies focus on the delivery of drug molecules to either decrease bone resorption or increase bone formation rather than regulating the entire bone remodeling process, and osteoporosis interventions suffer from this limitation. Here, we present a multifunctional nanoparticle based on metal-phenolic networks (MPNs) for the treatment of systemic osteoporosis by regulating both osteoclasts and osteoblasts. In the osteoporotic microenvironment, the MPN nanoparticles degrade and trigger the release of bioactive metals (strontium ions, SrII) to promote osteogenesis and functionalized Phenols (epigallocatechin gallate, EGCG) to suppress osteoclastogenesis. Injecting these nanoparticles into the tail vein of an ovariectomized mouse model, trabecular bone loss has been significantly prevented in the femoral head and vertebrae, along with increased trabecular bone volume and decreased trabecular bone separation. Overall, this work represents a versatile approach to explore MPN nanomaterials for the treatment of systemic osteoporosis and related orthopedic diseases.

Keywords

MPN nanoparticles; bone targeting; osteoblastic bone formation; osteoclastic bone resorption; osteoporosis.

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