2. Academic Validation
  3. Three new polyketides isolated from the Karst cave-derived Streptomyces sp. FD-2-6

Three new polyketides isolated from the Karst cave-derived Streptomyces sp. FD-2-6

  • Nat Prod Res. 2025 Feb 7:1-8. doi: 10.1080/14786419.2025.2460103.
Xuehao Hu 1 2 3,  Xiu Yang 1 2 3,  Liangqun Li 1 2,  Lijuan Ge 1 2,  Qiji Li 1 2,  Xiaosheng Yang 1 2,  Juan Yang 1 2,  Ming Gao 1 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China.
  • 2 Natural Products Research Center of Guizhou Province, Guiyang, China.
  • 3 College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
PMID: 39918543 DOI: 10.1080/14786419.2025.2460103
Abstract

Three new polyketides, actinofuranones J (1) and K (2), nocapyrone S (3), with one known compound nocapyrone Q (4) were isolated from the culture broth of a Karst cave-derived Streptomyces sp. (FD-2-6). Their structures were elucidated by comprehensive analysis of NMR spectroscopic data, HR-MS and electronic circular dichroism (ECD) data. The antitumour and Antibacterial activities of 1-4 were investigated by examining their IC50 and MIC values in MCF-7 human breast Cancer cells, human hepatocellular carcinoma HepG2 cells and human cervical Cancer Hela cells, and Klebsiella pneumoniae sp, Pseudomonas aeruginosa sp, Mycolicibacterium smegmatis sp, Escherichia coli sp, Staphylococcus aureus sp. Compounds 1-4 showed weak inhibitory effect on antitumour activity on MCF-7 human breast Cancer cells, and human cervical Cancer Hela cells.

Keywords

Karst cave; Polyketides; Streptomyces sp.; antibacterial activity; antitumour.

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