2. Academic Validation
  3. Resveratrol affects proliferation, apoptosis and migration of fibroblast cells as well as inhibits COL1A1/2 and TGFB2/3 gene expression

Resveratrol affects proliferation, apoptosis and migration of fibroblast cells as well as inhibits COL1A1/2 and TGFB2/3 gene expression

  • J Asian Nat Prod Res. 2025 Feb 18:1-21. doi: 10.1080/10286020.2025.2462610.
Mei-Li Li 1,  Kun Pang 2 3,  Lei Qiao 1,  Zhi-Qiang Guan 4,  Chao-Ju Gong 1,  Song-Tao Li 5,  Zhi-Ming Tang 6,  Yi-Ling Zhang 7,  Ji-Cun Ding 5
Affiliations

Affiliations

  • 1 Department of Ophthalmology, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou First People's Hospital, Eye Disease Prevention and Treatment Institute of Xuzhou, Xuzhou221002, China.
  • 2 Department of Urology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou221009, China.
  • 3 Department of Urology, Peixian People's Hospital, Peixian221699, China.
  • 4 Department of Dermatology, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou First People's Hospital, Xuzhou221002, China.
  • 5 Department of Burn and Plastic Surgery, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou First People's Hospital, Xuzhou221002, China.
  • 6 Department of Dermatology, Xuzhou Hospital of Traditional Chinese Medicine, Xuzhou221010, China.
  • 7 Department of Dermatology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou221009, China.
PMID: 39964130 DOI: 10.1080/10286020.2025.2462610
Abstract

Primary fibroblasts isolated from pterygium and skin pathological scar were identified by immunofluorescence staining. It was found by CCK8 and TUNEL that high-dose resveratrol, a Chinese medicine monomer, could inhibit proliferation, promote Apoptosis and restrain migration. Explored by whole-transcriptome Sequencing and LC-MS/MS, 1531 up-regulated mRNAs, 1022 down-regulated mRNAs, 79 up-regulated proteins and 84 down-regulated proteins were identified in resveratrol-treated pterygium fibroblasts. It was shown by KEGG, GO, PPI and the following bioinformatics analysis that resveratrol may affect proliferation, Apoptosis and migration of fibroblast through TGFB2/3 and COL1A1/2.

Keywords

COL1A1/2; Fibroblasts; TGFB2/3; pterygium; resveratrol; skin pathological scars.

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