2. Academic Validation
  3. Enhancing Osteogenesis through Bio-Inspired Recombinant Coral Protein Galaxin by Targeting Mitochondrial Metabolism and ATP Production

Enhancing Osteogenesis through Bio-Inspired Recombinant Coral Protein Galaxin by Targeting Mitochondrial Metabolism and ATP Production

  • Adv Sci (Weinh). 2025 Mar 8:e2412867. doi: 10.1002/advs.202412867.
Fei Yu 1,  Xing Zhao 2 3,  Ting Jiang 4,  Ningjuan Ouyang 5,  Peilin Li 1,  Wei Yang 6,  Zhihe Zhao 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
  • 2 Department of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China.
  • 3 Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, 610031, China.
  • 4 Department of Pediatric Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
  • 5 Department of Orthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
  • 6 College of Polymer Science and Engineering, Med-X Center for Materials, Sichuan University, Chengdu, 610065, China.
PMID: 40056046 DOI: 10.1002/advs.202412867
Abstract

Bio-inspired coral-derived scaffolds have been adopted for bone regeneration. However, these confront challenges such as the limited osteoinductive properties, environmental concerns, and ambiguous calcification mechanisms in coral proteins. In this study, the role of the recombinant coral protein galaxin in promoting osteogenesis is investigated. The observations reveal that recombinant galaxin regulates the Mitochondrial Metabolism in mouse pre-osteoblasts by interacting with the β subunit of ATP Synthase. This ultimately promotes osteogenesis of pre-osteoblasts. Furthermore, galaxin is integrated with gelatin methacryloyl (GelMA) and assess the osteogenic potential of the resulting galaxin-GelMA composites in mouse mandibular defects. The observations emphasize the distinctive role of galaxin in regulating mitochondrial functionality and osteogenesis. Additionally, these provide prospective insights for further applications of bio-inspired recombinant coral proteins in regenerative medicine.

Keywords

bio‐inspired; bone regeneration; coral; galaxin; mitochondrial metabolism.

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