2. Academic Validation
  3. Curcumol attenuates hyperproliferation and inflammatory response in a psoriatic HaCaT keratinocyte model by inhibiting the PI3K-Akt pathway and ameliorates skin lesions and inflammatory status in psoriasis-like mice

Curcumol attenuates hyperproliferation and inflammatory response in a psoriatic HaCaT keratinocyte model by inhibiting the PI3K-Akt pathway and ameliorates skin lesions and inflammatory status in psoriasis-like mice

  • Inflammopharmacology. 2025 Mar 10. doi: 10.1007/s10787-025-01708-y.
Mutian Niu # 1 2,  Xiaolong Li # 1 2,  Mingzhao Li 1 2,  Fangru Chen 3,  Hui Cao 4,  Qingbo Liu 1,  Bin Liang 1,  Guangyu Pan 1 2,  Chengqin Liang 5,  Jintao Gao 6 7
Affiliations

Affiliations

  • 1 School of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin, 541199, Guangxi, People's Republic of China.
  • 2 Key Laboratory of Molecular Medical Engineering, Education Department of Guangxi Zhuang Autonomous Region, Guilin, 541199, Guangxi, People's Republic of China.
  • 3 Department of Dermatology, Affiliated Hospital of Guilin Medical University, Guilin, 541001, Guangxi, People's Republic of China.
  • 4 Department of Dermatology, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, Guangxi, People's Republic of China.
  • 5 School of Pharmacy, Guilin Medical University, Guilin, 541199, People's Republic of China. cqliang@glmc.edu.cn.
  • 6 School of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin, 541199, Guangxi, People's Republic of China. jintao_gao@glmc.edu.cn.
  • 7 Key Laboratory of Molecular Medical Engineering, Education Department of Guangxi Zhuang Autonomous Region, Guilin, 541199, Guangxi, People's Republic of China. jintao_gao@glmc.edu.cn.
  • # Contributed equally.
PMID: 40063187 DOI: 10.1007/s10787-025-01708-y
Abstract

Psoriasis, a chronic autoimmune disorder, is characterized by keratinocyte hyperproliferation and inflammatory responses. Curcumol, a bioactive terpenoid, possesses antiproliferative and anti-inflammatory properties. This study evaluates the efficacy of curcumol in treating psoriasis in both in vitro and in vivo models. In vitro, curcumol inhibits hyperproliferation and inflammatory responses in a psoriatic HaCaT keratinocyte model stimulated by M5 cytokines by inhibiting the PI3K-Akt pathway. Additionally, in vivo, curcumol ameliorates psoriasis-like skin lesions and inflammatory status in imiquimod-induced mice. Network pharmacology revealed that curcumol's beneficial effects might involve the PI3K-Akt signaling pathway. Further investigation shows that curcumol partially counteracts the activation of PI3K-Akt by recilisib in keratinocytes. These results suggest that curcumol may be a promising therapeutic option for psoriasis.

Keywords

Curcumol; Inflammation; Keratinocytes; Proliferation; Psoriasis.

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