2. Academic Validation
  3. Curdlan/chitosan NIR-responsive in situ forming gel: An injectable scaffold for the treatment of epiphyseal plate injury

Curdlan/chitosan NIR-responsive in situ forming gel: An injectable scaffold for the treatment of epiphyseal plate injury

  • Int J Biol Macromol. 2025 Mar 14;308(Pt 1):142052. doi: 10.1016/j.ijbiomac.2025.142052.
Yi-Hao Guo 1,  Yi-Bin Yu 2,  Jia-Jun Wu 2,  Ya-Kun Kan 1,  Xiao Wu 3,  Zhuo Wang 4
Affiliations

Affiliations

  • 1 The First Hospital of China Medical University, Shenyang 110122, China.
  • 2 Health Sciences Institute, China Medical University, Shenyang 110122, China.
  • 3 He University, Shenyang 110163, China. Electronic address: wuxiao@huh.edu.cn.
  • 4 Health Sciences Institute, China Medical University, Shenyang 110122, China. Electronic address: zwang19@cmu.edu.cn.
PMID: 40090650 DOI: 10.1016/j.ijbiomac.2025.142052
Abstract

Premature closure of the epiphyseal plate inducing by the formation of bone bridges after epiphyseal plate injury, can lead to limb shortening and angular deformity, causing adverse effects on the growth and development of adolescents. Therefore, preventing the formation of bone bridges has become the primary task for children with epiphyseal plate fractures. In our study, a novel near-infrared (NIR)-responsive bone repair scaffold (CGCB), namely black phosphorus (BP)-loaded in-situ gel based on curdlan (CUD), β-glycerophosphate (GP) and chitosan (CS), was developed. In vitro studies confirmed that the CGCB can promote the differentiation and migration of chondrocytes and has potential cartilage repair ability. A drilled model of epiphyseal plate injury further confirmed that CGCB can promote the repair of epiphyseal plate injury and NIR irradiation combined with CGCB significantly repaired the injury site by increasing expression of Sox9 and Aggrecan. The above findings indicate that the near-infrared (NIR) responsive bone repair scaffold (CGCB) can effectively inhibit bone bridge formation, prevent early closure of the epiphyseal plate, and provide new ideas for repairing epiphyseal plate defects in children.

Keywords

Black phosphorus; Bone repair scaffold; Chitosan; Curdlan; Epiphyseal plate injury.

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