2. Academic Validation
  3. RNA-Binding Motif Protein 22 Induces Apoptosis via c-Myc Pathway in Colon Cancer Cells

RNA-Binding Motif Protein 22 Induces Apoptosis via c-Myc Pathway in Colon Cancer Cells

  • Molecules. 2025 Mar 9;30(6):1227. doi: 10.3390/molecules30061227.
Ye-Rin Park 1 2,  So-Mi Park 1 2,  Nanyeong Kim 1 2,  Jihoon Jung 1 2,  Seokwoo Kim 1 2,  Kwan-Il Kim 1 3,  Hyeung-Jin Jang 1 2
Affiliations

Affiliations

  • 1 College of Korean Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
  • 2 Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
  • 3 Division of Allergy, Immune and Respiratory System, Department of Internal Medicine, College of Korean Medicine, Kyung Hee University Medical Center, Kyung Hee University, 23, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
PMID: 40142004 DOI: 10.3390/molecules30061227
Abstract

RNA-binding motif 22 (RBM22) is an RNA-binding protein involved in gene regulation, with the capacity to bind DNA and function as a transcription factor for various target genes. Recent studies demonstrated that RBM22 depletion affects cell viability and proliferation of glioblastoma and breast Cancer cells. However, the role of RBM22 in colon Cancer and the molecular mechanisms underlying its tumor-suppressive function remain largely unclear. In this study, we demonstrate that RBM22 induces Apoptosis and suppresses colon Cancer cell viability and proliferation by modulating c-Myc expression. Furthermore, RBM22 knockdown reduces c-Myc stability. Therefore, our findings suggest that RBM22 depletion regulates Cancer cell proliferation and induces Apoptosis via the c-Myc pathway.

Keywords

CNOT2; MID1IP1; RBM22; c-Myc; colorectal cancer.

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