2. Academic Validation
  3. 2-Fluoroformycin and 2-aminoformycin. Synthesis and biological activity

2-Fluoroformycin and 2-aminoformycin. Synthesis and biological activity

  • J Med Chem. 1985 Nov;28(11):1740-2. doi: 10.1021/jm00149a033.
J A Secrist 3rd,  A T Shortnacy,  J A Montgomery
PMID: 4068000 DOI: 10.1021/jm00149a033
Abstract

Syntheses of 2-fluoroformycin [7-amino-5-fluoro-3-(beta-D-ribofuranosyl)pyrazolo[4,3-d]pyrimidine] (2b) and 2-aminoformycin [5,7-diamino-3-(beta-D-ribofuranosyl)pyrazolo[4,3-d]pyrimidine] (2c) are described. Cytotoxicity data are given for 2b and 2c alone as well as with added pentostatin. Kinetic parameters for Adenosine Deaminase are also provided. 2-Fluoroformycin, although a much poorer substrate for Adenosine Deaminase than formycin A, is not nearly as cytotoxic to cells in culture.

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