2. Academic Validation
  3. Brocresine in Parkinson's disease. Action of a peripheral and central decarboxylase inhibitor in potentiating levodopa

Brocresine in Parkinson's disease. Action of a peripheral and central decarboxylase inhibitor in potentiating levodopa

  • J Neurol Neurosurg Psychiatry. 1973 Feb;36(1):27-9. doi: 10.1136/jnnp.36.1.27.
P M Howse,  W B Matthews
PMID: 4570903 DOI: 10.1136/jnnp.36.1.27
Abstract

Brocresine, an aromatic L-amino acid decarboxylase inhibitor with both a peripheral and central action was shown to potentiate the therapeutic effect of levodopa in Parkinson's disease. The search for useful decarboxylase inhibitors therefore need not be limited to agents that do not pass the blood/brain barrier.

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