2. Academic Validation
  3. Effect of Met-enkephalin and (D-Met2,Pro5)-enkephalinamide on the adenylate cyclase activity of rat brain

Effect of Met-enkephalin and (D-Met2,Pro5)-enkephalinamide on the adenylate cyclase activity of rat brain

  • Neurochem Res. 1979 Oct;4(5):627-31. doi: 10.1007/BF00964439.
M Wollemann,  A Szebeni,  S Bajusz,  L Gráf
PMID: 492449 DOI: 10.1007/BF00964439
Abstract

Among opiatelike Peptides, stimulatory as well as inhibitory effects are encountered on Adenylate Cyclase activity. These actions are dependent not only on the investigated brain region but also on the applied peptide. Met-enkephalin stimulates Adenylate Cyclase activity in the rat brain stem (D-Met2, Pro5)-enkephalinamide and beta-endorphin inhibited it, whereas all three Peptides inhibited the activity of cortex. Naloxone antagonized the effects of the applied Peptides in the presence of sodium chloride.

Figures
Products