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  3. Metachromatic leukodystrophy: diagnosis with samples of venous blood

Metachromatic leukodystrophy: diagnosis with samples of venous blood

  • Science. 1968 Aug 9;161(3841):594-5. doi: 10.1126/science.161.3841.594.
A K Percy,  R O Brady
PMID: 5668537 DOI: 10.1126/science.161.3841.594
Abstract

Arylsulfatase A and B have been demonstrated in preparations of human leukocytes. The level of activity of arylsulfatase A is markedly decreased in the preparations from patients with metachromatic leukodystrophy. Acid Phosphatase and arylsulfatase B activities were normal. The assay of arylsulfatase A in leukocyte preparations can be useful in the diagnosis of metachromatic leukodystrophy while obviating the difficulties of current methods.

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