2. Academic Validation
  3. New antibiotics from the fungus Epicoccum nigrum. III. Epicorazine B: structure elucidation and absolute configuration

New antibiotics from the fungus Epicoccum nigrum. III. Epicorazine B: structure elucidation and absolute configuration

  • J Antibiot (Tokyo). 1978 Nov;31(11):1106-9. doi: 10.7164/antibiotics.31.1106.
G Deffieux,  M J Filleau,  R Baute
PMID: 569142 DOI: 10.7164/antibiotics.31.1106
Abstract

Comparison of UV, IR, PMR and CD spectra of epicorazine B with those of epicorazine A, a previously isolated metabolite of Epicoccum nigrum, showed that they were isomers with the same epidithiodiketopiperazine skeleton. X-Ray determination of epicorazine B indicated that the difference is related to a cis-trans configuration.

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