2. Academic Validation
  3. Pyrazolo[4,3-d]pyrimidine nucleosides. Synthesis and antiviral activity of 1-beta-D-ribofuranosyl-3-methyl-6-substituted-7H-pyrazolo[4,3-d]pyr imi din-7-ones

Pyrazolo[4,3-d]pyrimidine nucleosides. Synthesis and antiviral activity of 1-beta-D-ribofuranosyl-3-methyl-6-substituted-7H-pyrazolo[4,3-d]pyr imi din-7-ones

  • J Med Chem. 1984 Aug;27(8):986-90. doi: 10.1021/jm00374a009.
P G Baraldi,  D Simoni,  V Periotto,  S Manfredini,  M Guarneri,  R Manservigi,  E Cassai,  V Bertolasi
PMID: 6086926 DOI: 10.1021/jm00374a009
Abstract

N1 analogues of formycin B, with substituents at the 3 and 6 positions of the pyrazolo[4,3-d]pyrimidine moiety were synthesized by the direct SnCl4-catalyzed ribosylation method. The site of the glycosidic linkage and the anomeric configurations were established on the basis of X-ray crystallography, as well as 1H and 13C nuclear magnetic resonance spectroscopy. Preliminary results of the Antiviral testing of these derivatives in vitro are described.

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