2. Academic Validation
  3. Polyoxin D inhibits growth of zoopathogenic fungi

Polyoxin D inhibits growth of zoopathogenic fungi

  • Antimicrob Agents Chemother. 1983 Jun;23(6):926-9. doi: 10.1128/AAC.23.6.926.
J M Becker,  N L Covert,  P Shenbagamurthi,  A S Steinfeld,  F Naider
PMID: 6351734 DOI: 10.1128/AAC.23.6.926
Abstract

We demonstrated that polyoxin D at millimolar concentrations caused marked morphological alterations of the human pathogens Candida albicans and Cryptococcus neoformans. C. albicans incubated in the presence of this drug grew in long chains that were severely swollen. Polyoxin D inhibited the growth of C. neoformans and killed cells of both the yeast and the hyphal phase of C. albicans. These observations give the first evidence that polyoxin Antibiotics can kill zoopathogenic fungi.

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