2. Academic Validation
  3. Pharmacokinetics and bacteriological efficacies of apalcillin and cefpiramide in experimental pneumococcal meningitis

Pharmacokinetics and bacteriological efficacies of apalcillin and cefpiramide in experimental pneumococcal meningitis

  • Antimicrob Agents Chemother. 1984 Oct;26(4):578-9. doi: 10.1128/AAC.26.4.578.
K Sato,  S Shelton,  J D Nelson
PMID: 6517548 DOI: 10.1128/AAC.26.4.578
Abstract

Rabbits with experimentally induced pneumococcal meningitis were given single 25-mg/kg doses of apalcillin or cefpiramide. Mean percentages of the drug concentration in cerebrospinal fluid versus that in blood serum were 7.6% with apalcillin and 3.9% with cefpiramide. Bactericidal activity in cerebrospinal fluid resulted in mean reductions of from 4 to 5 log10 CFU/ml, and cerebrospinal fluid cultures became sterile for four of six Animals treated with each drug.

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