2. Academic Validation
  3. Drug latentiation of isoxsuprine: synthesis and preliminary pharmacological activities of four monoesters

Drug latentiation of isoxsuprine: synthesis and preliminary pharmacological activities of four monoesters

  • Farmaco Sci. 1983 Nov;38(11):904-10.
A Salimbeni,  E Manghisi,  G Ferni,  G B Fregnan
PMID: 6653775
Abstract

Four new esters (1 b-e) involving the phenolic group of isoxsuprine have been prepared. Preliminary pharmacological evaluation showed that the pivaloyl ester (1 e) (LR693) lowers blood pressure values more gradually than isoxsuprine with a longer-lasting effect. This compound was selected for further assessment as a long-acting peripheral vasodilator.

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