2. Academic Validation
  3. Novel antitumor agents CI-920, PD 113,270 and PD 113,271. I. Taxonomy, fermentation and biological properties

Novel antitumor agents CI-920, PD 113,270 and PD 113,271. I. Taxonomy, fermentation and biological properties

  • J Antibiot (Tokyo). 1983 Dec;36(12):1595-600. doi: 10.7164/antibiotics.36.1595.
J B Tunac,  B D Graham,  W E Dobson
PMID: 6689323 DOI: 10.7164/antibiotics.36.1595
Abstract

CI-920 (PD 110,161) and two analogues (PD 113,270 and PD 113,271) are novel antitumor compounds produced by a new actinomycete characterized as Streptomyces pulveraceus subsp. fostreus ATCC 31906. The antitumor compounds are predominantly produced during the stationary (idiophase) growth phase of the organism. CI-920 is active versus the murine P388 lymphocytic and L1210 lymphoid leukemia with T/C values of 246 and 207, respectively. This compound has no significant antimicrobial activity.

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