2. Academic Validation
  3. Cytostatic quinones. 3. Synthesis of benzotriazolequinones by a new oxidation with m-chloroperbenzoic acid. Biochemical studies

Cytostatic quinones. 3. Synthesis of benzotriazolequinones by a new oxidation with m-chloroperbenzoic acid. Biochemical studies

  • J Med Chem. 1978 Jun;21(6):578-82. doi: 10.1021/jm00204a014.
G Alonso,  A Contreras,  M Fuertes,  J M Infante,  F G de las Heras,  M Stud
PMID: 671455 DOI: 10.1021/jm00204a014
Abstract

Oxidation of N-1 and N-2 alkylbenzotriazoles with m-chloroperbenzoic acid afforded 1-alkylbenzotriazole 3-oxides and 2-alkylbenzotriazole-4,4-diones, respectively. The quinonic compounds inhibited the "in vitro" growth of both HeLa and KB cells, the synthesis of macromolecules (DNA, RNA, and proteins), and the uptake of glucose by Ehrlich carcinoma ascites cells. A possible mode of action is suggested.

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