2. Academic Validation
  3. Gilvocarcins, new antitumor antibiotics. 3. Antitumor activity

Gilvocarcins, new antitumor antibiotics. 3. Antitumor activity

  • J Antibiot (Tokyo). 1981 Jun;34(6):701-7. doi: 10.7164/antibiotics.34.701.
M Morimoto,  S Okubo,  F Tomita,  H Marumo
PMID: 6792176 DOI: 10.7164/antibiotics.34.701
Abstract

Gilvocarcin V, isolated rom a Streptomyces culture showed activity against experimental tumors such as sarcoma 180, Ehrlich carcinoma, Meth 1 fibrosarcoma, MH134 hepatoma and lymphocytic leukemia P388. In particular, 40% of treated mice survived for 60 days, after intraperitoneal administration of gilvocarcin V to mice bearing Ehrlich ascites carcinoma. But it was marginally active against B16 melanoma and did not produce prolongation of lifespan of mice bearing Lewis lung carcinoma.

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