2. Academic Validation
  3. C-19393 E5, a new carbapenem antibiotic. Fermentation, isolation and structure

C-19393 E5, a new carbapenem antibiotic. Fermentation, isolation and structure

  • J Antibiot (Tokyo). 1982 Aug;35(8):957-62. doi: 10.7164/antibiotics.35.957.
S Harada,  Y Nozaki,  S Shinagawa,  K Kitano
PMID: 6815148 DOI: 10.7164/antibiotics.35.957
Abstract

A new carbapenem Antibiotic, C-19393 E5, was isolated from the culture filtrate of Streptomyces griseus subsp. cryophilus C-19393 as a minor component. The chemical structure of the Antibiotic was determined by comparing its spectral data with those of the known 5,6-cis carbapenem Antibiotics and confirmed by partial synthesis from epithienamycin B as shown in Fig. 1. The Antibiotic has a broad antimicrobial spectrum and shows strong inhibitory activity against beta-lactamases.

Figures
Products