2. Academic Validation
  3. Vanoxonin, a new inhibitor of thymidylate synthetase

Vanoxonin, a new inhibitor of thymidylate synthetase

  • J Antibiot (Tokyo). 1983 Jun;36(6):656-60. doi: 10.7164/antibiotics.36.656.
F Kanai,  T Sawa,  M Hamada,  H Naganawa,  T Takeuchi,  H Umezawa
PMID: 6874588 DOI: 10.7164/antibiotics.36.656
Abstract

Vanoxonin, a new inhibitor of thymidylate synthetase, was found in cultured broths of the strain MG245-CF2 classified as Saccharopolyspora hirsuta. Vanoxonin, C18H25N3O9, was obtained as colorless powder. Vanoxonin forms a vanadium complex which exhibits a strong inhibition against thymidylate synthetase. The concentration for 50% inhibition of the Enzyme (IC50) was 0.7 micrograms/ml.

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