2. Academic Validation
  3. Plant anticancer agents. XXIII. 6 alpha-senecioyloxychaparrin, a new antileukemic quassinoid from Simaba multiflora

Plant anticancer agents. XXIII. 6 alpha-senecioyloxychaparrin, a new antileukemic quassinoid from Simaba multiflora

  • J Nat Prod. 1983 Mar-Apr;46(2):218-21. doi: 10.1021/np50026a015.
M Arisawa,  A D Kinghorn,  G A Cordell,  N R Farnsworth
PMID: 6875576 DOI: 10.1021/np50026a015
Abstract

Fractionation of an aqueous ethanol extract of the wood of Simaba multiflora afforded a new antineoplastic quassinoid, 6 alpha-senecioyloxychaparrin (5), and two known quassinoids 6 alpha-senecioyloxychaparrinone (1) and chaparrinone (2). The structure of 5, which displayed activity against the KB and P-388 test systems, was established through the interpretation of spectral data.

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