[Biotransformation and pharmacokinetics of mesionic didehydro-4-methyl-5-phenyl-1,3,4-thiadiazolidine-2-thione (LU 2443). Studies on the pharmacokinetics in rats]

After p.o. application in rats the pharmacokinetic properties of the mesionic dihydro-4-methyl-5-phenyl-1,3,4-thiadiazolidine-2-thione (LU 2443) were examined. The compound is extensively absorbed, in the maximum 18% are eliminated unabsorbed. The half-time of the activity in plasma is 13.17 h, the highest concentration in plasma after p.o. application as a solution of polyethyleneglycol is reached after 5.09 h. The elimination is mainly renal--namely 61.9%, 28.7% are eliminated with the faeces. After 96 h 90.6% of the applicated activity was eliminated. The distribution of LU 2443 was in the whole organism; entrance of the compound into liquor was proven. By radiography of the total animal a transient accumulation of LU 2443 and its metabolites in liver and kidney was determined; besides, a considerable concentration of activity in the suprarenal medulla was found.