2. Academic Validation
  3. Degenerate perturbations of protein structure as the mechanism of anaesthetic action

Degenerate perturbations of protein structure as the mechanism of anaesthetic action

  • Nature. 1978 Dec;276(5690):775-9. doi: 10.1038/276775a0.
C D Richards,  K Martin,  S Gregory,  C A Keightley,  T R Hesketh,  G A Smith,  G B Warren,  J C Metcalfe
PMID: 723953 DOI: 10.1038/276775a0
Abstract

The interaction of the n-alkanols with lipid bilayers and excitable membranes shows that there is no simple correlation between conduction block and any of the perturbations of bilayer structure currently proposed as unitary mechanisms of local anaesthetic action. We propose instead that the n-alkanols act by direct interaction with target proteins to cause perturbations which depend directly on the precise structure of the alcohol.

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