2. Academic Validation
  3. New anthracyclines, feudomycins, produced by the mutant from Streptomyces coeruleorubidus ME130-A4

New anthracyclines, feudomycins, produced by the mutant from Streptomyces coeruleorubidus ME130-A4

  • J Antibiot (Tokyo). 1981 Jul;34(7):783-90. doi: 10.7164/antibiotics.34.783.
T Oki,  Y Matsuzawa,  K Kiyoshima,  A Yoshimoto,  H Naganawa,  T Takeuchi,  H Umezawa
PMID: 7287580 DOI: 10.7164/antibiotics.34.783
Abstract

Various blocked mutants were isolated from Streptomyces coeruleorubidus ME130-A4 by NTG and UV treatments. Among them, mutant strain 4N-140 produced new anthracycline feudomycins A and B having new aglycones in which the side chain at C-9 position of daunomycinone was ethyl and acetonyl, respectively. New aglycones feudomycinones C and D having methyl at C-9 and additional groups at C-10 of daunomycinone were also isolated from this strain.

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