2. Academic Validation
  3. Preparation and biological activities of 10-decarbamoyloxy-9-dehydromitomycin B and its analogs

Preparation and biological activities of 10-decarbamoyloxy-9-dehydromitomycin B and its analogs

  • J Antibiot (Tokyo). 1981 Sep;34(9):1152-6. doi: 10.7164/antibiotics.34.1152.
C Urakawa,  H Tsuchiya,  K Nakano,  N Nakamura
PMID: 7328056 DOI: 10.7164/antibiotics.34.1152
Abstract

A new naturally occurring mitomycin, 10-decarbamoyloxy-9-dehydromitomycin B (1), was prepared by treating mitomycin B with sodium hydride. Its analogs having an exo-cyclic double bond in their structure were also synthesized. These compounds showed Antibacterial and cytotoxic activities. Among them, 7-amino-10-decarbamoyloxy-9-dehydro-7-demethoxymitomycin B (2) was the most potent growth inhibitor of KB cells in vitro and, accordingly, it appears to be a potential antitumor agent.

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