2. Academic Validation
  3. Inhibition by idrocilamide of the disposition of caffeine

Inhibition by idrocilamide of the disposition of caffeine

  • Eur J Clin Pharmacol. 1980 Jan;17(1):37-43. doi: 10.1007/BF00561675.
J L Brazier,  J Descotes,  N Lery,  M Ollagnier,  J C Evreux
PMID: 7371698 DOI: 10.1007/BF00561675
Abstract

The pharmacokinetics of caffeine are greatly altered by concomitant administration of idrocilamide. In four healthy volunteers id rocilamide inhibited the biotransformation of caffeine and increased its half-life nine times. The untoward neuropsychiatric effects of idrocilamide are the consequence of abnormal accumulation of caffeine in regular consumers of caffeine-containing foods and beverages.

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