2. Academic Validation
  3. Spiroquinazoline, a novel substance P inhibitor with a new carbon skeleton, isolated from Aspergillus flavipes

Spiroquinazoline, a novel substance P inhibitor with a new carbon skeleton, isolated from Aspergillus flavipes

  • J Nat Prod. 1994 Apr;57(4):471-6. doi: 10.1021/np50106a005.
C J Barrow 1,  H H Sun
Affiliations

Affiliation

  • 1 Natural Products Chemistry, Sterling Winthrop Pharmaceuticals Research Division, Malvern, PA 19355.
PMID: 7517439 DOI: 10.1021/np50106a005
Abstract

A novel substance P inhibitor, spiroquinazoline [1], was isolated from the fungus Aspergillus flavipes, which was originally obtained from soil. The structure of 1 was determined by analysis of spectroscopic data and 1 was shown to contain a new carbon skeleton containing a spiro-carbon center. Also isolated from the same culture extract were the new natural product, benzodiazepiedione [3], and the known compounds, acyl aszonalenin [4], N-benzoyl-L-phenylalaninol, and seven diketopiperazines.

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