2. Academic Validation
  3. The mniopetals, new inhibitors of reverse transcriptases from a Mniopetalum species (Basidiomycetes). I. Producing organism, fermentation, isolation and biological activities

The mniopetals, new inhibitors of reverse transcriptases from a Mniopetalum species (Basidiomycetes). I. Producing organism, fermentation, isolation and biological activities

  • J Antibiot (Tokyo). 1994 Jul;47(7):733-9. doi: 10.7164/antibiotics.47.733.
A Kuschel 1,  T Anke,  R Velten,  D Klostermeyer,  W Steglich,  B König
Affiliations

Affiliation

  • 1 LB Biotechnology, The University, Kaiserslautern, FRG.
PMID: 7520899 DOI: 10.7164/antibiotics.47.733
Abstract

Six novel Enzyme inhibitors of RNA-directed DNA-polymerases of human immunodeficiency-, avian myeloblastosis and murine leukemia viruses were isolated from fermentations of a canadian Mniopetalum species. They were named mniopetals A, B, C, D, E and F. Their structures were elucidated by spectroscopic methods. The compounds, in addition to their inhibitory activities on reverse transcriptases, exhibit antimicrobial and cytotoxic properties.

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