2. Academic Validation
  3. Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

  • Nature. 1995 Aug 31;376(6543):737-45. doi: 10.1038/376737a0.
S Lev 1,  H Moreno,  R Martinez,  P Canoll,  E Peles,  J M Musacchio,  G D Plowman,  B Rudy,  J Schlessinger
Affiliations

Affiliation

  • 1 Department of Pharmacology, New York University Medical Center, New York 10016, USA.
PMID: 7544443 DOI: 10.1038/376737a0
Abstract

The protein tyrosine kinase Pyk2, which is highly expressed in the central nervous system, is rapidly phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration, as well as by protein kinase C activation. Activation of Pyk2 leads to modulation of ion channel function and activation of the MAP kinase signalling pathway. Pyk2 activation may provide a mechanism for a variety of short- and long-term calcium-dependent signalling events in the nervous system.

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