2. Academic Validation
  3. [Cytotoxicity of aspidospermane indole alkaloids with a modified tryptamine chain]

[Cytotoxicity of aspidospermane indole alkaloids with a modified tryptamine chain]

  • J Nat Prod. 1995 Jul;58(7):1089-91. doi: 10.1021/np50121a018.
G Lewin 1
Affiliations

Affiliation

  • 1 Laboratoire de Pharmacognosie, Faculté de Pharmacie, Caen, France.
PMID: 7561901 DOI: 10.1021/np50121a018
Abstract

Eight synthetic Indole Alkaloids with the aspidospermane structure have ben evaluated for cytotoxicity in the L-1210 Cell Culture test system. Two of them (compounds 9 and 5), bearing a modified tryptamine chain, were significantly active (IC50 values of 0.7 and 3.1 microM, respectively).

Figures