2. Academic Validation
  3. Macquarimicins, microbial metabolites from Micromonospora. II. Isolation and structural elucidation

Macquarimicins, microbial metabolites from Micromonospora. II. Isolation and structural elucidation

  • J Antibiot (Tokyo). 1995 Jun;48(6):467-70. doi: 10.7164/antibiotics.48.467.
J E Hochlowski 1,  M M Mullally,  R Henry,  D M Whittern,  J B McAlpine
Affiliations

Affiliation

  • 1 Abbott Laboratories, Abbott Park, Illinois 60064, USA.
PMID: 7622431 DOI: 10.7164/antibiotics.48.467
Abstract

A novel series of carbocyclic compounds has been isolated from two related Micromonospora cultures. The C-19 and C-22 macquarimicins represent different end products on a similar biosynthetic scheme. 1-D and 2-D homonuclear and heteronuclear NMR experiments allowed assignment of the basic structures of the macquarimicins. An X-ray structure of macquarimicin B suggested the stereochemistry for the series which was not discernible from spectroscopic data alone.

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