2. Academic Validation
  3. Fusacandins A and B; novel antifungal antibiotics of the papulacandin class from Fusarium sambucinum. II. Isolation and structural elucidation

Fusacandins A and B; novel antifungal antibiotics of the papulacandin class from Fusarium sambucinum. II. Isolation and structural elucidation

  • J Antibiot (Tokyo). 1995 Jul;48(7):614-8. doi: 10.7164/antibiotics.48.614.
J E Hochlowski 1,  D N Whittern,  A Buko,  L Alder,  J B McAlpine
Affiliations

Affiliation

  • 1 Abbott Laboratories, Abbott Park, Illinois 60064, USA.
PMID: 7649857 DOI: 10.7164/antibiotics.48.614
Abstract

Two novel Antifungal compounds of the papulacandin class, named fusacandins A and B, have been isolated from Fusarium sambucinum. Each compound contains two units of galactose and one of glucose, the latter connected as a C-glycoside to an aromatic moiety. Fusacandin A is esterified at two sites with long-chain, unsaturated fatty acids and fusacandin B at only one site. The structures of the fusacandins were elucidated through analysis of mass spectral and 1-D and 2-D homonuclear and heteronuclear NMR data.

Figures
Products