2. Academic Validation
  3. Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protein transferase

Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protein transferase

  • Appl Microbiol Biotechnol. 1993 Nov;40(2-3):370-4. doi: 10.1007/BF00170395.
R B Lingham 1,  K C Silverman,  G F Bills,  C Cascales,  M Sanchez,  R G Jenkins,  S E Gartner,  I Martin,  M T Diez,  F Peláez
Affiliations

Affiliation

  • 1 Merck Research Laboratories, Rahway, NJ 07065.
PMID: 7764394 DOI: 10.1007/BF00170395
Abstract

Chaetomellic acids A and B, isolated from Chaetomella acutiseta, are specific inhibitors of farnesyl-protein transferase that do not inhibit geranylgeranyl transferase type 1 or squalene synthase. Chaetomellic acids A and B are reversible inhibitors, resemble farnesyl diphosphate and probably inhibit FPTase by substituting for farnesyl diphosphate. Chaetomellic acid production appears to be widespread within the genus Chaetomella.

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