Indole alkaloids from Peschiera laeta that enhance vinblastine-mediated cytotoxicity with multidrug-resistant cells

J Nat Prod. 1994 Nov;57(11):1517-22. doi: 10.1021/np50113a007.

M You ¹, X Ma, R Mukherjee, N R Farnsworth, G A Cordell, A D Kinghorn, J M Pezzuto

Affiliations

Affiliation

1 Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Illinois 60612.

PMID: 7853002 DOI: 10.1021/np50113a007

Abstract

Coronaridine [1], conoduramine [2], and voacamine [3], three Indole Alkaloids isolated from Peschiera laeta, have been found to enhance the cytotoxic response mediated by vinblastine [4] with multidrug-resistant KB cells. Inhibition of vinblastine binding with membrane vesicles isolated from this cell line was also assessed, and the bisindole Alkaloids conoduramine [2] and voacamine [3] were found to be more potent inhibitory agents than the monomeric alkaloid, coronaridine [1]. Thus, these compounds appear to function by binding with P-glycoprotein.

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