2. Academic Validation
  3. Bacithrocins A, B and C, novel thrombin inhibitors

Bacithrocins A, B and C, novel thrombin inhibitors

  • J Antibiot (Tokyo). 1994 Sep;47(9):959-68. doi: 10.7164/antibiotics.47.959.
T Kamiyama 1,  T Umino,  Y Nakamura,  Y Itezono,  S Sawairi,  T Satoh,  K Yokose
Affiliations

Affiliation

  • 1 Nippon Roche Research Center, Kanagawa, Japan.
PMID: 7928697 DOI: 10.7164/antibiotics.47.959
Abstract

Novel Thrombin inhibitors, bacithrocins A, B and C, have been isolated from the culture broth of Bacillus laterosporus Laubach NR 2988. The structures of these inhibitors have been determined to be N-acyl-L-phenylalanyl-DL-arginal by the 2D-NMR experiments on their oxidation products and by amino acid analysis. Bacithrocin A inhibits Thrombin, Factor Xa and trypsin with IC50s of 48, 13 and 0.65 microM, respectively, which are similar to those of bacithrocins B and C. Bacithrocins prolong the clotting time induced by Thrombin and Factor Xa.

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